Sin is the greatest problem of the entire human race, not sickness nor poverty. Sin entered the world through Adam's disobedience and was passed down from generation to generation.
"When Adam sinned, the entire world was affected. Sin entered human experience, and death was the result. And so death followed this sin, casting its shadow over all humanity, because all have sinned" (Romans 5:12 TPT).
The consequence of sin is death, that is spiritual death. Spiritual death is the separation of man from God even though the sinner is alive. As long as the sinner is still alive, spiritual death has remedy.
Romans 6:23(a) says, "For the wages of sin is death;..."
If the sinner remains in the state of spiritual death and dies without Christ, ETERNAL DEATH will be the outcome. This is suffering in the lake of fire which has no remedy. It is forever, this is the highest form of death sin brings.
Revelation 20:15 says, "And whosoever was not found written in the book of life was cast into the lake of fire".
To me, this is the greatest consequence of sin. It is the bad news that necessitated the good news (gospel). Wealth, health, influence cannot reverse this consequence. That is why the true gospel is the only solution to avert this for mankind.
Imagine someone burning and getting tormented day and night non stop. This will be the end of everyone without Christ. If you can picture hell, you will not desire your worst enemy to go there. Hell is not God's will for mankind.
"Then shall he say also unto them on the left hand, Depart from me, ye cursed, into EVERLASTING FIRE, PREPARED FOR THE DEVIL AND HIS ANGELS" (Mt 25:41 KJV).
If truly, eternal fire was prepared for Satan and his angels, mankind have no business going there. Meaning that hell is now a choice. Unfortunately, when a man reject Christ, he chooses hell. The gospel shows the way out of this eternal quagmire.
Spiritual death not remedied will lead into eternal death that cannot be remedied. Spiritual death remedied produces eternal life devoid of eternal suffering.



